Sökning: "FARMACI Galenisk farmaci"
Visar resultat 1 - 5 av 56 avhandlingar innehållade orden FARMACI Galenisk farmaci.
1. Mechanical strength of pharmaceutical compacts : Importance of material characteristics, particle characteristics and compaction pressure on interparticulate bonding structure
Sammanfattning : Factors considered important for the interparticulate bonding structure and mechanical strength of pharmaceutical compacts were studied in this thesis.Fractures appear to propagate mainly around rather than through grains during strength testing. LÄS MER
2. In vitro and in silico prediction of drug-drug interactions with transport proteins
Sammanfattning : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. LÄS MER
3. Engineering of Pharmaceutical Particles : Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process
Sammanfattning : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. LÄS MER
4. New Concepts in Administration of Drugs in Tablet Form : Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System
Sammanfattning : This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. LÄS MER
5. Tabletting behaviour of aggregates : Mechanistical conception and modulation by variations in aggregate physical properties
Sammanfattning : The volume reduction mechanisms involved during compression of aggregates prepared from microcrystalline cellulose particles and effects of variations in their physical properties on their compression behaviour and compactability were studied in this thesis.The dominating volume reduction mechanisms during compression of aggregates prepared of MCC were deformation (bulk deformation and local deformation) parallel with densification, and generally the degree of fragmentation of the aggregates was minute. LÄS MER
