Sökning: "FARMACI Biofarmaci"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden FARMACI Biofarmaci.

  1. 1. In vitro and in silico prediction of drug-drug interactions with transport proteins

    Författare :Gustav Ahlin; Per Artursson; Christel Bergström; Johan Karlsson; Jörg König; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; Pharmaceutics; Galenisk farmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics; Biopharmaceutics; biofarmaci;

    Sammanfattning : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. LÄS MER

  3. 2. The Hepatobiliary Transport of Rosuvastatin In Vivo

    Författare :Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Sammanfattning : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. LÄS MER

  4. 3. Microdialysis as a tool in pharmacokinetic-pharmacodynamic studies investigating the brain distribution and effect delay of morphine and morphine-6-glucuronide

    Författare :Marcel René Bouw; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : The microdialysis technique was developed as a tool for studying the pharmacokinetic and pharmacodynamicrelationships of morphine and morphine-6-glucronide (M6G). Concentrations of unbound drug in blood andbrain were monitored in order to elucidate the origin of the observed delay in antinociceptive effect in rats. LÄS MER

  5. 4. Pharmacodynamic modeling of cardiovascular effects of Σb-antagonists and moxonidine : Special emphasis on tolerance and rebound effects

    Författare :Lena Brynne; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Pharmacodynamic (PD) modeling was used to characterize and quantify the short- and long-term changes in cardiovascular effects following treatment with β-antagonists or imidazoline receptor agonist moxonidine, in spontaneous hypertensive rats and patients with congestive heart failure, respectively. The complex cardiovascular system is regulated by several feedback mechanisms with different time domains and gains. LÄS MER

  7. 5. The pharmacokinetics and pharmacodynamics of clevidipine, a new ultrashort-acting calcium antagonist, in different animal species and man

    Författare :Hans Ericsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Clevidipine is a new ultrashort-acting calcium antagonist of the dihydropyridine type developed for reduction and control of blood pressure in connection with cardiac surgery. The aim of this thesis was to characterise the in vitro hydrolysis rate of clevidipine in different biological matrices and the pharmacokinetics and pharmacodynamics in animal species and various human populations. LÄS MER