Sökning: "Erik Nygren"

Hittade 2 avhandlingar innehållade orden Erik Nygren.

  1. 1. A mouse model for direct evaluation of cholera vaccines

    Författare :Erik Nygren; Göteborgs universitet; []
    Nyckelord :Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Sammanfattning : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). LÄS MER

  3. 2. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

    Författare :Yvonne Nygren; Erik Björn; Knut Irgum; Bente Gammelgaard; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. LÄS MER