Sökning: "Epitopes"

Visar resultat 1 - 5 av 266 avhandlingar innehållade ordet Epitopes.

  1. 1. Vaccine Therapy of Colorectal Cancer Patients with Tumor Associated Antigens

    Författare :Gustav Ullenhag; Håkan Mellstedt; Carl Magnusson; Bengt Glimelius; Torgny Stigbrand; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Oncology; Colorectal cancer; GM-CSF; vaccination; CEA; ALVAC-KSA; IgG subclass; epitopes; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : In this thesis, two different vaccines were evaluated as adjuvant therapy for patients with colorectal cancer. The ability of the two candidate vaccines to generate antigen-specific cellular and humoral responses, respectively, was studied. LÄS MER

  3. 2. Aspects of autoantibody epitopes in type 1 diabetes

    Författare :Hanna Skärstrand; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Minor autoantigens Neuropeptide Y.; Affinity; ZnT8 autoantibodies; Autoimmune type 1 diabetes;

    Sammanfattning : Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. LÄS MER

  4. 3. Seroepidemiology of vaccine-preventable and emerging RNA viruses in Rwanda

    Författare :Eric Seruyange; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seroprevalence; measles virus; rubella virus; Zika virus; West Nile virus; chikungunya virus; tick-borne encephalitis virus; mosquitoes; linear epitopes; Rwanda; Sweden;

    Sammanfattning : Abstract Infectious diseases are a leading cause of death in sub-Saharan Africa, and in Rwanda diarrhea, lower respiratory and other common infections are linked to high mortality and morbidity. For children ... LÄS MER

  5. 4. Biomedical Applications of Bacterial Cellulose Fermentation, Morphology and Surface Properties

    Författare :Aase Katarina Bodin; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biocompatibility; xyloglucan epitopes; mechanical properties; cell adhesion; tubular fermentation; morphology; Bacterial cellulose; surface properties; meniscus mold; crystal formation.; ozonation; adsorption;

    Sammanfattning : Because average life expectancy has increased and peoples lifestyles have changed, degenerative diseases have become a critical issue. The demand for biomedical materials to replace or improve major body systems (skeletal, circulatory and nervous, etc.) will increase as people strive to maintain good quality of life. LÄS MER

  7. 5. Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition

    Författare :Chin Shing Ho; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded human alpha-lactalbumin and oleic acid that kills many different types of tumor cells and shows therapeutic efficacy in animal models and clinical studies. This thesis aims to (1) elucidate the structure of HAMLET and the exposure of biologically active domains, (2) define the contribution of lipids to the tumoricidal effect of HAMLET, (3) characterize the membranes response to HAMLET and the perturbation of membrane associated signaling cascades, (4) use proteomic screens to identify conserved features of HAMLET targets in tumor cells. LÄS MER