Sökning: "EGR1"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet EGR1.

1. 1. Host-bacteria interactions : Host cell responses and bacterial pathogenesis

   Författare :Nele de Klerk; Ann-Beth Jonsson; Teresa Frisan; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Host-bacteria interaction; Helicobacter pylori; Neisseria gonorrhoeae; Lactobacillus; Epithelial cells; Macrophages; EGR1; Amphiregulin; SabA; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Helicobacter pylori colonizes the human stomach, where it causes gastritis that may develop into peptic ulcer disease or cancer when left untreated. Neisseria gonorrhoeae colonizes the urogenital tract and causes the sexually transmitted disease gonorrhea. LÄS MER

3. 2. Bacteria-host cell interactions : Studies on initial colonization, antimicrobial peptides, and biofilms

   Författare :Gabriela Wassing; Ann-Beth Jonsson; Elena Vikström; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neisseria meningitidis; Lactobacillus; host responses; EGR1; antimicrobial peptides; hBD2; A20; biofilm; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The obligate human pathogen Neisseria meningitidis asymptomatically colonizes the upper respiratory tract, but crossing of the epithelial barrier can cause life-threatening meningitis and/or sepsis. N. LÄS MER

4. 3. Interplay between bacteria and host epithelial cells

   Författare :Lisa Maudsdotter; Ann-Beth Jonsson; Cindy Grove Arvidson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbial-cell interaction; Adherence; Infection; Lactic acid bacteria; Antimicrobial peptides; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Bacterial pathogens have developed multiple ways of manipulating host cell functions to exploit the host environment. We found that interactions with epithelial cells increase the resistance of the human pathogen Neisseria meningitidis to the antimicrobial peptide LL-37. LÄS MER

5. 4. Human Bone Marrow Microenvironment in Health and Disease

   Författare :Sandro Bräunig; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

   Sammanfattning : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. LÄS MER

7. 5. Molecular mechanisms of the transcriptional co-activator mastermind-like 1

   Författare :Magnus L Hansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Gene regulation is a complex process that requires several types of proteins, including chromatin-modifying enzymes, transcription factors, co-activators and co-repressors. We have investigated the molecular mechanisms underlying the action of the co-activator protein MAML1, which was first identified as a transcriptional co-activator for Notch receptors. LÄS MER