Sökning: "Dehydrogenase"

Visar resultat 1 - 5 av 283 avhandlingar innehållade ordet Dehydrogenase.

  1. 1. 2nd and 3rd generation electrodes for biosensors and biofuel cells

    Författare :MNadeem Zafar; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; WrbA; pyranose dehydrogenase; cellobiose dehydrogenase; glucose dehydrogenase; direct electron transfer; Os-polymers; mediated electron transfer; single-walled carbon nanotubes; amperometric biosensor; biofuel cell; screen-printed electrodes; flow injection analysis; cascade reaction; bioanode;

    Sammanfattning : The catalytic and electrochemical properties of tryptophan repressor-binding protein (WrbA), pyranose dehydrogenase (PDH), cellobiose dehydrogenase (CDH) and glucose dehydrogenase (GDH) on carbon electrodes were investigated using cyclic voltammetry and flow injection amperometry to construct biosensors and biofuel cell (BFC) anodes. WrbA has a catalytic FMN-containing domain whereas both PDH and GDH have a catalytic FAD-containing domains. LÄS MER

  3. 2. Inhibitors of Human and Malaria Parasite Dihydroorotate Dehydrogenase

    Författare :Ingela Fritzson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DHODH; Synthesis; Inhibitors.; Dihydroorotate dehydrogenase;

    Sammanfattning : In the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. LÄS MER

  4. 3. Characterization and Directed Evolution of an Alcohol Dehydrogenase : A Study Towards Understanding of Three Central Aspects of Substrate Selectivity

    Författare :Emil Hamnevik; Mikael Widersten; Gerrit Poelarends; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alcohol dehydrogenase; ADH-A; Biocatalysis; Directed evolution; Enantioselectivity; Enzyme kinetics; Enzyme mechanisms; Protein Engineering; Regioselectivity; Substrate selectivity; Biokemi; Biochemistry;

    Sammanfattning : Many different chemicals are used in the everyday life, like detergents and pharmaceuticals. However, their production has a big impact on health and environment as much of the raw materials are not renewable and the standard ways of production in many cases includes toxic and environmentally hazardous components. LÄS MER

  5. 4. On the role of cellobiose dehydrogenase in cellulose biodegradation

    Författare :Martin Kruså; KTH; []
    Nyckelord :cellobiose dehydrogenase; methyl b-d-glucopyranoside; hydroxyl radical;

    Sammanfattning : .... LÄS MER

  7. 5. Gene fusion in protein engineering : design of novel peptides and bifunctional enzymes

    Författare :Sarah Fredriksson; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cadmium; Bifunctional enzyme; Catalytic triad; Channeling; Coenzyme recycling; Galactose dehydrogenase; ß-Galactosidase; Gene fusion; Hexapeptide; Lactate dehydrogenase; Linker region; Multifunctional enzymes; Oligomeric protein; NADH; Phage; OmpA; Biochemistry; Biokemi; metabolism; Biotechnology; Bioteknik;

    Sammanfattning : The gene fusion technique is widely used in protein engineering and in this thesis it constitutes the basis of both the construction of artificial bifunctional enzymes and the display of two novel peptides. Artificial bifunctional enzymes have been used as model systems in the studies of native multifunctional enzymes and proximity effects within these complexes. LÄS MER