Sökning: "DNA-microarrays"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet DNA-microarrays.

  1. 1. Metabolic Engineering of Central Carbon Metabolism in Saccharomyces cerevisiae The contribution of systems biology to physiological studies

    Författare :Marta Papini; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fermentation technology; Metabolic engineering; RNA-sequencing; Saccharomyces cerevisiae; DNA microarrays; 13Cbased flux analysis; system biology; Scheffersomyces stipitis;

    Sammanfattning : Saccharomyces cerevisiae is one of the most well characterized yeast of large industrial interest due to several attractivefeatures such as its capability to efficiently convert glucose into ethanol and carbon dioxide at high flux, its amenabilityto genetic modification and the presence of extensive knowledge databases. For these reasons, it is often considered asuitable cell factory for the production of different classes of compounds. LÄS MER

  3. 2. Statistical analysis of gene expression data

    Författare :Erik Kristiansson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gene expression; DNA microarrays; linear models; empirical Bayes; quality control; gene regulation; categorical data analysis; logistic regression; heavy metal stress; ecotoxicology; gene expression;

    Sammanfattning : Microarray technology has become one of the most important tools for genome-wide mRNA measurements. The technique has been successfully applied to many areas in modern biology including cancer research, identification of drug targets, and categorization of genes involved in the cell cycle. LÄS MER

  4. 3. Integration of functional genomics and data mining methodologies in the study of bipolar disorder and schizophrenia

    Författare :Marianthi Logotheti; Nikolaos Venizelos; Fragiskos Kolisis; Nikos Stefanis; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar Disorder; Schizophrenia; Fibroblasts; DNA Microarrays; Machine Learning; Functional Analysis; Gene Expression; Transcriptomics;

    Sammanfattning : Bipolar disorder and schizophrenia are two severe psychiatric disorders characterized by a complex genetic basis, coupled to the influence of environmental factors. In this thesis, functional genomic analysis tools were used for the study of the underlying pathophysiology of these disorders, focusing on gene expression and function on a global scale with the application of high-throughput methods. LÄS MER

  5. 4. Vitreoscilla Haemoglobin. Genetic Fusions and Metabolic Characterisation

    Författare :Viktoria Roos; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Metabolism; Biokemi; metabolism; osmotic stress; transcript profiling; DNA microarrays; random elongation mutagenesis; directed evolution; mRNA structure; Vitreoscilla haemoglobin VHb ; Escherichia coli; salt stress.;

    Sammanfattning : Vitreoscilla is an obligate aerobic bacterium living in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla expresses a homodimeric haemoglobin (VHb) when subjected to oxygen-limited conditions. LÄS MER

  7. 5. Regulation of Fibroblast Activity by Keratinocytes

    Författare :Daniel Nowinski; Mikael Ivarsson; Bengt Gerdin; Elof Ph D M.D. Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; conective tissue growth factor; interleukin-1; fibroblast; keratinocyte; wound healing; burns; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : In the healing of cutaneous wounds, paracrine communication between keratinocytes and fibroblasts regulates cell differentiation, proliferation and synthesis of extracellular matrix. Deficient epidermal coverage, as seen in burn-wounds, frequently results in hypertrophic scars. LÄS MER