Sökning: "DNA compaction"
Visar resultat 1 - 5 av 25 avhandlingar innehållade orden DNA compaction.
1. DNA Compaction at Surfaces
Sammanfattning : The interfacial behavior of DNA and DNA-cationic surfactant has been studied. Particular attention was paid to the type of cationic surfactant and the DNA conformation (single or double stranded) as well as the DNA length. LÄS MER
2. Controlling DNA compaction and the interaction with model biomembranes
Sammanfattning : The studies described in this thesis forms part of a larger collaborative project, Neonuclei, with the objective to design a module for packaging the negatively charged DNA into a ”neonucleus” with transcription competence. There are many applications that require control of DNA compaction, i.e. packaging or condensation. LÄS MER
3. Association of Amphiphiles and Polyelectrolytes with DNA
Sammanfattning : DNA- cationic amphiphile and DNA-cationic polymer systems were studied with respect to the intermolecular interactions, as well as structure and stability of formed complexes. The thesis is divided in two parts: one section is a summary and the other section contains five papers. LÄS MER
4. Protein Folding and DNA Origami
Sammanfattning : In this thesis, the folding process of the de novo designed polypeptide chignolin was elucidated through atomic-scale Molecular Dynamics (MD) computer simulations. In a series of long timescale and replica exchange MD simulations, chignolin’s folding and unfolding was observed numerous times and the native state was identified from the computed Gibbs free-energy landscape. LÄS MER
5. DNA Tetraplexes and Nucleosome Positioning Sequences
Sammanfattning : All eukaryotic organisms package their genomes into a nucleoprotein complex known as chromatin, whose major constituents are the DNA and proteins known as histones. The non-covalent association of histones with DNA results in considerable compaction and allows the organisation of the genome into the cell nucleus. LÄS MER
