Sökning: "DNA base analogs"

Hittade 5 avhandlingar innehållade orden DNA base analogs.

  1. 1. Fluorescence Probing of DNA Structures in Biology and Nanotechnology

    Författare :Peter Sandin; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA; Fluorescent DNA base analog; UV‐Vis spectroscopy; DNA nanostructure; self‐assembly; time‐resolved fluorescence spectroscopy;

    Sammanfattning : Much has been learnt about DNA since its structure was discovered about half a century ago. Scientists everlasting urge to look beyond and deeper into the intricate machinery of life, has continuously pushed technology forward. LÄS MER

  3. 2. Fluorescent DNA Modifications for Use as Probes of Biological Structure and as Nanotechnological Functional Units

    Författare :Karl Börjesson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; FRET; nanotechnology; DNA; DNA base analogs; fluorescence; porphyrin; lipid membrane;

    Sammanfattning : .... LÄS MER

  4. 3. Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA

    Författare :Pernilla Wittung; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fluorescence; RecA; homologous recombination; circular dichroism; DNA analogs; -anti-BPDE; spectroscopy; PNA; DNA-protein interactions;

    Sammanfattning : The work presented in this thesis focuses on interactions between nucleic-acids in biological systems, particularly interactions of the promising drug-candidate peptide nucleic acid (PNA), and on protein-DNA intermediates during recombination. Several experimental techniques, mainly circular dichroism and fluorescence spectroscopy, have been used to characterize the interactions of interest. LÄS MER

  5. 4. DNA analogs for the purpose of gene therapy

    Författare :Mathias G Svahn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes DNA analogs and their potential use for gene therapeutic purposes, primarily by sequence specific strand-invasion of double-stranded DNA. Gene therapy is classically thought of as restoration of a defect gene. LÄS MER

  7. 5. Crystal structures of human deoxyribonucleotidases

    Författare :Agnes Rinaldo-Matthis; Pär Nordlund; David K Stammers; Stockholms universitet; []
    Nyckelord :crystal structure;

    Sammanfattning : Human 5’-deoxyribonucleotidases are ubiquitous enzymes that catalyze the dephosphorylation of deoxyribonucleoside monophosphates to their nucleoside form. They participate in the regulation of deoxyribonucleotide pools and protect DNA replication from inbalance of precursors. LÄS MER