Sökning: "DFO"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet DFO.

  1. 1. Mitochondrial Iron Metabolism : Study of mitoferrin in Drosophila melanogaster

    Författare :Christoph Metzendorf; Maria Lind Karlberg; Kenneth Söderhäll; Martina Muckenthaler; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; iron; Drosophila; mitochondria; mitoferrin; ferritin; spermatogenesis; cell cycle; DFO; MRS12; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Sammanfattning : Iron has a dualistic character. On the one hand it is essential for the life of most organisms, on the other hand it is involved in the generation of reactive oxygen species that are implicated in diseases and aging. LÄS MER

  3. 2. Radiolabelled affibody molecules for imaging EGFR expression in tumours

    Författare :Maryam Oroujeni; Vladimir Tolmachev; Martin Behe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; ZEGFR:2377; radionuclide molecular imaging; PET; SPECT; labelling chemistry.;

    Sammanfattning : Affibody molecules are promising scaffold-based targeting proteins for radionuclide imaging and cancer therapy. This thesis is based on 5 original research articles (Papers I-V), with the primary focus being placed on the optimization of molecular design of EGFR-binding affibody variants for high contrast imaging of epidermal growth factor receptor (EGFR) expression in tumours. LÄS MER

  4. 3. Optimization of in vivo cell tracking methods with long-lived radionuclides for PET imaging

    Författare :Ida Friberger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Stem cell transplantation and cell therapy are the standard treatments for many diseases; however, many suffer from complications, and the therapeutic efficiency can be challenging to predict. The off-target accumulation of the transplanted cells can cause some of these shortcomings. LÄS MER

  5. 4. Relation between nutritional status, the outcome of infection and immune responses

    Författare :Graciela Terán; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A causal interaction between nutrition and the outcome of different infections has been known since long time ago. Moreover, responses of human beings to infection are diverse and demarcated by immunity. A deficient and unappropriated nutrition allows to a deficient immune response. LÄS MER

  7. 5. Oxidized Lipids and Lysosomal Pathology in Atherogenesis

    Författare :Wei Li; Wendy Jessup; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Macrophages take up large amount of exogenous materials such as oxidatively modified low-density lipoproteins (oxLDL) and lysosomotropic agents. OxLDL is taken up into macrophage lysosomes through receptor-mediated endocytosis, but poorly degraded, resulting in foam cell formation. LÄS MER