Sökning: "DEK-NUP214"

Hittade 2 avhandlingar innehållade ordet DEK-NUP214.

  1. 1. Molecular Mechanisms of the DEK Protein in Leukemia

    Författare :Carl Sandén; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DEK; DEK-NUP214; fusion gene; acute myeloid leukemia; proliferation; mTOR; ChIP-seq;

    Sammanfattning : The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. LÄS MER

  3. 2. On the role of the fusion protein DEK-NUP214 in leukemogenesis

    Författare :Malin Ageberg; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA translation; Medicin människa och djur ; fusion gene; Medicine human and vertebrates ; leukemia;

    Sammanfattning : The t(6;9) translocation is found in a subset of patients with acute myeloid leukemia (AML) and is associated with a poor prognosis. The translocation results in the formation of the DEK-NUP214 fusion protein containing almost the entire nuclear protein DEK and two thirds of the nucleoporin NUP214. LÄS MER