Sökning: "D-optimal experiment design"

Hittade 2 avhandlingar innehållade orden D-optimal experiment design.

1. 1. Computational Diffusion MRI: Optimal Gradient Encoding Schemes

   Författare :Mohammad Alipoor; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gradient Encoding Scheme; ADC imaging; Diffusion MRI; D-optimal experiment design; Diffusion Tensor Imaging; Optimal Image acquisition; Second and Fourth Order Tensors.; Diffusion Kurtosis Imaging;

   Sammanfattning : Diffusion-weighted magnetic resonance imaging (dMRI) is a non-invasivestructural imaging technique that provides information about tissue microstructures.Quantitative measures derived from dMRI reflect pathologicaland developmental changes in living tissues such as human brain. LÄS MER

3. 2. Optimal design for dose-finding studies

   Författare :Renata Eirini Tsirpitzi; Frank Miller; Kirsten Schorning; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bivariate model; distortion; drug combination; Elfving set; Emax model; Fedorov algorithm; mixed effects models; optimal experimental design; Statistics; statistik;

   Sammanfattning : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. LÄS MER