Sökning: "D-optimal design"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden D-optimal design.
1. Experimental Designs at the Crossroads of Drug Discovery
Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER
2. Optimal Design of Experiments for the Quadratic Logistic Model
Sammanfattning : Optimal design of experiments for binary data is the topic of this thesis. A particular logistic model including a quadratic term in the linear predictor is considered. Determining an optimal design for this model is complicated by the fact that the optimal design is dependent on the unknown true parameters. LÄS MER
3. Computational Diffusion MRI: Optimal Gradient Encoding Schemes
Sammanfattning : Diffusion-weighted magnetic resonance imaging (dMRI) is a non-invasivestructural imaging technique that provides information about tissue microstructures.Quantitative measures derived from dMRI reflect pathologicaland developmental changes in living tissues such as human brain. LÄS MER
4. Optimal design for dose-finding studies
Sammanfattning : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. LÄS MER
5. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications
Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER