Sökning: "CysLT1R"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet CysLT1R.

  1. 1. Regulation and Function of the Human Leukotriene D4 Receptor CysLT1 in Epithelial Cells and Colon Cancer

    Författare :Christian Kamp-Nielsen; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; Inflammation; PKC; Calcium; CysLT1R; GPCR; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : The pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. LÄS MER

  3. 2. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Författare :Astrid Bengtsson; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Sammanfattning : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. LÄS MER

  4. 3. LTD4 signalling via beta-catenin: a possible link between inflammation and cancer

    Författare :Maryna Mezhybovska; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; beta-catenin; colorectal cancer; CysLT1R; proliferation; inflammation;

    Sammanfattning : The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. LÄS MER

  5. 4. The role of CysLT1R in animal models of colorectal cancer

    Författare :Sayeh Savari; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. LÄS MER

  7. 5. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

    Författare :Syrina Mehrabi; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

    Sammanfattning : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. LÄS MER