Sökning: "Costimulation"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet Costimulation.

  1. 1. Costimulation Blockade in Experimental Transplantation

    Författare :Helene Malm; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; serologi; Immunologi; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; graft survival; anti-CD40L; CTLA4Ig; anti-LFA-1; costimulation blockade;

    Sammanfattning : Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. LÄS MER

  3. 2. On the induction and function of Foxp3+ regulatory T cells

    Författare :Cecilia Oderup; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; regulatory T cell; serology; Immunology; superantigen; costimulation; dendritic cell; Foxp3;

    Sammanfattning : This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. LÄS MER

  4. 3. Transforming Growth Factor-b, Regulatory functions on normal lymphocytes and tumor outgrowth Regulatory functions on normal lymphocytes and tumor outgrowth

    Författare :Åsa Schiött; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-b; monocyte; rat; costimulation; Th2; ERK; tumor; TIL; Immunology; serology; Immunologi; transplantation; T-lymphocyte; serologi;

    Sammanfattning : Transforming growth factor-beta (TGF-b) is a well-characterised growth regulatory factor, which acts on most cell types. This thesis has focused on the regulatory roles of TGF-b on normal lymphocytes. One interesting finding is that TGF-b acts both costimulatory and inhibitory on T-lymphocytes. LÄS MER

  5. 4. Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis

    Författare :Ellen Marks; Göteborgs universitet; []
    Nyckelord :Chlamydia; T cell differentiation; genital tract; vaccination; costimulation; Th1; Th2; Th17; Tregs;

    Sammanfattning : Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, including the recently discovered Th17 subset, during genital tract infection with a common sexually transmitted pathogen, Chlamydia trachomatis, and addresses vaccine requirements for the generation of genital tract CD4+ T cell immunity. LÄS MER

  7. 5. Studies on the function of CD4CD25 regulatory T cells: An in vitro approach

    Författare :Lukas Cederbom; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; CD152; Costimulation; Dendritic cells; Regulatory T cells; CD4 CD25 ; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Immunological self-tolerance is a state of the whole organism where deleterious responses are either avoided or regulated. Breaking of immunological tolerance will lead to autoimmune disease or chronic inflammatory conditions. LÄS MER