Sökning: "Conformational investigations"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Conformational investigations.

  1. 1. Conformational Stability!? : Synthesis and Conformational Studies of Unnatural Backbone Modified Peptides

    Författare :Anna S. Norgren; Per I. Arvidsson; Norbert Sewald; Uppsala universitet; []
    Nyckelord :Organic chemistry; Conformational investigations; β-peptides; glycosylation; biomolecular recognition; cyclic β³-peptides; cyclic mixed α β²-peptides; β-peptoids; Organisk kemi;

    Sammanfattning : The beauty of the wide functionality of proteins and peptides in Nature is determined by their ability to adopt three-dimensional structures. This thesis describes artificial molecules developed to mimic secondary structures similar to those found crucial for biological activities. LÄS MER

  3. 2. NMR studies on calcium-induced conformational transitions in calmodulin

    Författare :Johan Evenäs; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; NMR; conformational exchange; calmodulin; calcium binding; Fysikalisk kemi;

    Sammanfattning : Nuclear magnetic resonance (NMR) spectroscopy was used in order to investigate the relationships between structure, dynamics and calcium binding in the intracellular regulatory protein, calmodulin. Calmodulin consists of two similar domains, each binding two calcium ions with positive cooperativity. LÄS MER

  4. 3. Synthesis of oligosaccharides for structural, conformational and molecular recognition investigations

    Författare :Peter Söderman; Inge Lundt; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : Carbohydrates are involved cell-cell interaction. Synthesis of small and medium sized oligosaccharides is important to gain more understanding about the their physical properties that are crucial for their action in molecular recognition events. LÄS MER

  5. 4. Structural Studies of Binding Proteins: Investigations of Flexibility, Specificity and Stability

    Författare :Ulrika Magnusson; Sherry L. Mowbray; Anthony J. Wikinson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Periplasmic binding protein; X-ray crystallography; conformational change; acidophile; protein specificity; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Binding proteins are present both in gram-negative and gram-positive bacteria. They are the recognition components of the ABC transport systems that transport different nutrients into the cell, and are in some cases also involved in chemotaxis. LÄS MER

  7. 5. Computational Modeling of Macrocycles and Structure-Based Design of Novel Antibacterial Compounds

    Författare :Gustav Olanders; Anders Karlén; Peter Brandt; Christian Sköld; Dan Sindhikara; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrocycles; docking; conformational sampling; conformational prefer-ences; antibiotics;

    Sammanfattning : The integration of computational methods into the drug discovery process provides valuable tools to help advance new and improved drugs into the clinic. As medicinal chemists explore novel targets and new areas of chemical space, our computational toolkit must also evolve. LÄS MER