Sökning: "Complement inhibition"
Visar resultat 1 - 5 av 57 avhandlingar innehållade orden Complement inhibition.
1. Complement in Disease - Extracellular Proteins as Complement Regulators
Sammanfattning : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. LÄS MER
2. The role of the thromboinflammatory response under hemolytic conditions : pathophysiological mechanisms and therapeutic inhibition
Sammanfattning : In blood circulation, the complement and the coagulation cascades, together with platelets and endothelial cells form a complex network of crosstalk. When dysregulated, these interactions can lead to inflammation in combination with thrombosis (thromboinflammation) and the manifestation of pathophysiological complications. LÄS MER
3. Synaptic elimination and the complement system in Alzhaimer's disease
Sammanfattning : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. LÄS MER
4. Effects of Complement Opsonization of HIV on Dendritic Cells : and Implications for the Immune Response
Sammanfattning : Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. LÄS MER
5. Complement-mediated kidney diseases: Genotype, phenotype and inhibition studies
Sammanfattning : Complement-mediated kidney diseases are ultrarare conditions characterized by excess complement activation related in most cases to complement gene variants or circulating autoantibodies. These conditions are chronic and can lead to kidney failure. LÄS MER