Sökning: "Clinical trials"

Visar resultat 1 - 5 av 754 avhandlingar innehållade orden Clinical trials.

  1. 1. The future of clinical trials for Alzheimer's disease. A blood-based biomarker perspective

    Författare :Nicholas Cullen; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Biomarkers; Cognition; Amyloid; Tau; Neurodegeneration;

    Sammanfattning : Objectives: The primary objective was to investigate the utility of blood-basedbiomarkers of amyloid, tau, and neurodegeneration for (i) screening, (ii)enrichment, and (iii) tracking response to treatment in clinical trials of Alzheimer’sdisease.Methods: Longitudinal, participant-level data used in these studies was drawn fromthe Swedish BioFINDER study and the ADNI study. LÄS MER

  3. 2. Patients in Clinical Cancer Trials : Understanding, Motivation and Hope

    Författare :Tove Godskesen; Ulrik Kihlbom; Peter Nygren; Karin Nordin; Peter Strang; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; adults; clinical trials; phase 1 trials; phase 3 trials; patient information; patient education; informed consent; hope;

    Sammanfattning : The overall aim of this thesis was to study participants' understanding of clinical cancer trials, and their motivation for participation. Of particular interest was the question of whether the patients hoped for a cure resulting from the trial. LÄS MER

  4. 3. Safety with Mechanical Chest Compressions in CPR : Clinical studies with the LUCAS™ device

    Författare :David Smekal; Sten Rubertsson; Michael Baubin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac arrest; Cardiopulmonary resuscitation; Mechanical chest compressions; Active compression-decompression; Injury; Autopsy; LUCAS; Medicin; Medicine;

    Sammanfattning : Chest compressions in cardiopulmonary resuscitation are of utmost importance although not without a risk. Many injuries are described but the incidence of these is hard to define due to methodological differences. It is strenuous to perform chest compressions and therefore mechanical chest compressions have been looked upon with interest. LÄS MER

  5. 4. Pharmacokinetics of antidepressant drugs : naturalistic and clinical trials

    Författare :Margareta Reis; Finn Bengtsson; Edoardo Spina; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Depression is a major public health problem and it is predicted to be the second leading cause of disease burden by the year 2020. The pharmacological treatment period for major depressive disorder (MDD) is relatively long and sometimes prophylactic over many years. LÄS MER

  7. 5. Bridging the gap between clinical trials and clinical practice : sacubitril-valsartan in heart failure as a model

    Författare :Helena Norberg; Krister Lindmark; Ellinor Bergdahl; Eva-Lotta Glader; Björn Wettermark; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systematic implementation; healthcare quality improvement; chronic disease management; heart failure; sacubitril-valsartan; real-world population; sex differences; kardiologi; Cardiology;

    Sammanfattning : When novel treatments prove more effective than standard therapies, a swift and effective implementation is needed to reach cost-effectiveness and to benefit eligible patients. Meanwhile, women and elderly are often under-represented in clinical trials, which creates a knowledge gap on how to optimize treatment in clinical practice. LÄS MER