Sökning: "Chlamydiae"

Hittade 5 avhandlingar innehållade ordet Chlamydiae.

  1. 1. Expanding the Chlamydiae tree : Insights into genome diversity and evolution

    Författare :Jennah E. Dharamshi; Thijs J. G. Ettema; Alexander Probst; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PVC superphylum; Chlamydiae; chlamydia; intracellular; symbiosis; endosymbiont; pathogen; marine sediment; sponge microbiome; metagenomics; uncultured microbial diversity; phylogenomics; microbial evolution; eukaryote evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : Chlamydiae is a phylum of obligate intracellular bacteria. They have a conserved lifecycle and infect eukaryotic hosts, ranging from animals to amoeba. Chlamydiae includes pathogens, and is well-studied from a medical perspective. LÄS MER

  3. 2. Chemical genetics discloses the importance of heme and glucose metabolism in Chlamydia trachomatis pathogenesis

    Författare :Patrik Engström; Sven Bergström; Ted Hackstadt; Umeå universitet; []
    Nyckelord :Chlamydiae; heme metabolism; glucose metabolism; glucose-6-phosphate; RB-to-EB transition; molekylärbiologi; Molecular Biology;

    Sammanfattning : Chlamydiae are important human bacterial pathogens with an intracellular life cycle that consists of two distinct bacterial forms, an infectious form (EB) that infects the eukaryotic host cell, and a non-infectious form (RB) that allows intracellular proliferation. To be successful, chlamydiae need to alternate between EB and RB to generate infectious EB’s which are competent to infect new host cells. LÄS MER

  4. 3. Regulation of Attachment and Early Intracellular Development of Chlamydia trachomatis in Eucaryotic Cells

    Författare :Meytham Majeed; Martin Lindberg; Östergötlands Läns Landsting; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The obligate intracellular bacterium, Chlamydia trachomatis , a common human pathogen, causing different diseases in both males and females, as well as in infants born to infected mothers. Occasionally, these diseases involve serious complications, such as blindness and infertility. C. LÄS MER

  5. 4. Small molecule inhibitors of type III secretion and their effect on chlamydia development

    Författare :Sandra Muschiol; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chlamydiae are obligate intracellular pathogens that cause a variety of diseases with clinical and public health importance. Like many Gram-negative bacteria, Chlamydiae employ a type III secretion (T3S) system for invasion and establishment of a protected intracellular niche for successful replication and survival within host cells. LÄS MER

  7. 5. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Författare :Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER