Sökning: "Cell and Organism Biology"
Visar resultat 6 - 10 av 136 avhandlingar innehållade orden Cell and Organism Biology.
6. Systems biology of protein synthesis and secretion in yeast
Sammanfattning : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. LÄS MER
7. Regulation of cellular Hsp70 : Proteostasis and aggregate management
Sammanfattning : Proteins have to be folded to their native structures to be functionally expressed. Misfolded proteins are proteotoxic and negatively impact on cellular fitness. To maintain the proteome functional proteins are under the constant surveillance of dedicated molecular chaperones that perform protein quality control (PQC). LÄS MER
8. Chromatin, histones, and epigenetic tags
Sammanfattning : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). LÄS MER
9. Ribonucleotide reductase and DNA damage
Sammanfattning : A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. LÄS MER
10. Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells
Sammanfattning : The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. LÄS MER