Sökning: "Caspase-2"

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet Caspase-2.

  1. 6. Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein

    Författare :Karin Anestål; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thioredoxin reductase; TrxR1; SecTRAPs; selenoproteins; apoptosis; caspase-2; glutathione reductase; cisplatin;

    Sammanfattning : The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) are selenoproteins containing a selenocysteine (Sec) residue within a carboxyl terminal -Gly -Cys -Sec -Gly -COOH motif. LÄS MER

  3. 7. On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha

    Författare :Theocharis Panaretakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anti-cancer drugs act primarily by inducing apoptosis. However, knowledge of how various substances induce apoptosis is still incomplete, and so is the basis for the great variation in cellular sensitivity to cytotoxic drugs. LÄS MER

  4. 8. Acute myeloid leukemia : apoptotic signalling and gene expression associated with treatment response

    Författare :Marita Lagergren Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a severe, life threatening malignancy characterized by a clonal expansion of immature myeloid cells in the bone marrow, resulting in severe infections and bleedings. High dose chemotherapy is able to normalize the blood and bone marrow morphology (complete remission, CR) in a majority of treated patients, but recurrent disease, typically occurs within 1-2 years. LÄS MER

  5. 9. Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma

    Författare :Xiangning Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus which infects more than 90% of individuals in the population, and has been shown to be associated with a variety of human tumors. The viral genome encodes a number of transforming proteins which enable the virus to efficiently immortalize B lymphocyte and also transform cells of other types. LÄS MER

  7. 10. Anti-Apoptotic Proteins in Nerve Cell Survival and Neurodegeneration

    Författare :Laura Korhonen; Marja Jäättelä; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; neuronal cell death; XIAP; RIAP-2; Hippocalcin; Bcl-2; Bcl-X; kainic acid; DRG; estrogen; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; medicinsk utvecklings- och neurobiologi;

    Sammanfattning : Apoptosis is a genetically regulated cell death program, which shows distinct morphological characteristics. It takes place during neuronal development and in some neurodegenerative diseases. During apoptosis, the intracellular proteins are degraded by various caspases, cysteine aspartases, which are regulated by pro- and anti-apoptotic signals. LÄS MER