Sökning: "Caspase-2"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet Caspase-2.

  1. 11. Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia

    Författare :Edward Laane; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acute leukemia; glucocorticoids; doxorubicin; apoptosis; autophagy; minimal residual disease; dendritic cells;

    Sammanfattning : Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult myeloid AL (AML). LÄS MER

  3. 12. Transcriptional regulation of cell life and death decisions by p73

    Författare :Naveen Reddy Muppani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : p73 is the second member to be identified within the p53 family and shares structure and functions with p53. P73 generates various isoforms, which include full-length transcriptionally active (TA) isoforms and amino-terminal transactivation domain-deficient (ΔN) isoforms. LÄS MER

  4. 13. Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246

    Författare :Jinfeng Shen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in cell cycle arrest, senescence, apoptosis, etc. Mutations in p53 occur frequently (around 50%) in many human tumors. LÄS MER

  5. 14. Experimental radioimmunotherapy and effector mechanisms

    Författare :David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; Immunology; Immunologi;

    Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER

  7. 15. Apoptotic cell death in neural stem cells exposed to toxic stimuli

    Författare :Christoffer Tamm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neural stem cells (NSCs) play an important role in the developing nervous system and in the adult brain, where mitotic regions such as the subventricular zone (SVZ) remain active. In spite of the intense ongoing research on NSCs, we still need to expand the knowledge on biochemical regulation by which NSCs undergo cell death in the course of normal physiology or in response to neurotoxic insults. LÄS MER