Sökning: "CYP2J2"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet CYP2J2.

  1. 1. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

    Författare :Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. LÄS MER

  3. 2. Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation

    Författare :Ibrahim El-Serafi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens given prior to HSCT. LÄS MER

  4. 3. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Författare :Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. LÄS MER

  5. 4. Pharmacovigilance of preventive chemotherapy for the control of schistosomiasis and soil-transmitted helminths in Ethiopia

    Författare :Tigist Dires Gebreyesus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The World Health Organization (WHO) recommends preventive chemotherapy (PC) as a core public health intervention for the control and elimination of schistosomiasis and soil transmitted helminths (STHs) in endemic countries. Despite being amenable to available treatments and ongoing PC, schistosomiasis and STHs remain causes of significant morbidity and associated complications in endemic areas. LÄS MER

  7. 5. Pharmacovigilance of mass drug administration for the control of schistosomiasis and soil transmitted helminths in Rwanda

    Författare :Joseph Kabatende; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Preventive chemotherapy (PC) is a WHO recommended core interventional measure or a strategy to prevent, control and eliminate STH and schistosomiasis as public health burden by 2030. Though preventable and treatable, they are still endemic in Rwanda and continue to cause significant mortality and morbidity. LÄS MER