Sökning: "CYNOMOLGUS MONKEYS"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden CYNOMOLGUS MONKEYS.

  1. 1. Oncogenic mechanisms of AIDS-related neoplasia in humans and SIV infected monkeys

    Författare :Esmeralda Castaños-Vélez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :immunosuppression; AIDS; lymphoma; Kaposi s sarcoma; EBV HVMF-1; HHV8; cell proliferation; apoptosis; animal model;

    Sammanfattning : Patients with AIDS or immunosuppressive post-transplant therapy are at high risk to develop Kaposi's sarcoma (KS) and malignant lymphoma that represent clinically lethal complications. Lymphomagenesis in simian immunodeficiency virus (SIV) infected cynomolgus monkeys has been shown to be highly similar to lymphomagenesis in immunosuppressed patients. LÄS MER

  3. 2. Testosterone and the postmenopausal breast : aspects on cell proliferation and mammographic density

    Författare :Marie Hofling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Menopause; testosterone; breast cell proliferation; fine needle aspiration biopsy; mammographic density; Syndecan-1; androgen receptor; cynomolgus macaques;

    Sammanfattning : The breast is a target organ for sex steroids, and hormonal treatments have been associated with a risk of breast cancer. There is increasing interest in androgen treatment for postmenopausal women. Testosterone has been shown to improve bone density, body composition, mood, psychosexual function and general well-being. LÄS MER

  4. 3. Methods for detection of HIV-2/SIV infections

    Författare :Lilian Walther Jallow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective of this thesis was to develop and improve laboratory methods for detection of HIV-2 in infected humans and detection of HIV-2/SIV in experimentally infected cynomolgus monkeys. Early in the HIV epidemic no assays were commercially available for detection of HIV-2/SIV infections and laboratory testing often relied on cross-reactivity in the assays. LÄS MER

  5. 4. HIV and SIV specific cellular immunity in macaque models

    Författare :Barbro Mäkitalo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cellular immunity is believed to be an important prerequisite for an effective HIV vaccine. Accruing data from individuals able to contain HIV-1 replication during natural infection underscores the contribution of CD8+ T cells in viral control. LÄS MER

  7. 5. Virus tropism and neutralization response in SIV infection

    Författare :Anna Laurén; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; Medicin människa och djur ; Medicine human and vertebrates ; HIV; SIV; mode of CCR5 use; CD4-independence; macrophage tropism; coreceptor use; neutralization; evolution; pathogenesis;

    Sammanfattning : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. LÄS MER