Sökning: "CTLs"

Visar resultat 1 - 5 av 45 avhandlingar innehållade ordet CTLs.

  1. 1. Diffuse large B-cell lymphoma – studies on immunohistochemical and clinical prognostic factors

    Författare :Sverker Hasselblom; Göteborgs universitet; []
    Nyckelord :DLBCL; prognosis; sex; population-based; apoptosis; Ki-67; CTLs; TIA-1; FOXP3; bcl-2; GCB; p-AKT;

    Sammanfattning : DLBCL, the most common lymphoma entity, is a potentially curable but heterogeneous disease. Most studies concerning therapy and prognostic factors have been performed on selected patient materials. It is important to identify immunohistochemical biomarkers which could add prognostic information to clinical factors. LÄS MER

  3. 2. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Författare :Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Sammanfattning : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. LÄS MER

  4. 3. Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands

    Författare :Michael Uhlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CD8 T cells; APL; CTLs; non-responsiveness; AICD; lck; lipid rafts; partial agonism; TCR activation.;

    Sammanfattning : CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). LÄS MER

  5. 4. Neuroblastoma as a target for effector mechanisms of the immune system

    Författare :Anna De Geer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma (NB) is the most common solid extracranial tumor in children. Despite intensive multimodal treatment, the prognosis for high-risk NB patients remains poor and therefore new treatment modalities are needed. The main aim of my studies was to assess NB as a target for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. LÄS MER

  7. 5. The HER2/neu oncoprotein and dendritic cells in immunity against tumors

    Författare :Yang Rongcun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HER2 neu; dendritic cells; ovarian carcinoma; apoptosis;

    Sammanfattning : It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T lymphocytes (CTLs). A number of tumor antigens recognized by CTLs on human melanomas have been defined, but less is known about antigens from other tumor types. LÄS MER