Sökning: "CML"

Visar resultat 1 - 5 av 53 avhandlingar innehållade ordet CML.

  1. 1. Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate

    Författare :Yuan Wei; Göteborgs universitet; []
    Nyckelord :CML; imatinib; BCR-ABL; apoptosis; mutation; T-lymphocyte;

    Sammanfattning : The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule inhibitor of the BCR-ABL tyrosine kinase, is now the first-line treatment for all newly diagnosed chronic phase CML patients. LÄS MER

  3. 2. Targeting NOX2 in cancer

    Författare :Ebru Aydin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; reactive oxygen species; immunotherapy; nox2; nk cells; melanoma; histamine; metastasis; leukemia; aml; cml; kras; mpd;

    Sammanfattning : Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. LÄS MER

  4. 3. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma

    Författare :Cecilia Weigelt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; SAg; SEA; SEAm; HLA class II; TCR; CFL; SDCC; cytotoxicity; TNF a; IFN g; mAb; PA-SEAm; anti-CD19-Fab-SEAm; B-CLL; B-NHL; AML; CML; immunotherapy; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

    Sammanfattning : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. LÄS MER

  5. 4. Modelling animal populations

    Författare :Åke Brännström; Umeå universitet; []
    Nyckelord :population model; stochastic population model; population dynamics; discrete time model; Beverton-Holt model; Skellam model; Hassell model; Ricker model; first principles; coupled map lattice; CML; area integral; square function; Mathematics; matematik;

    Sammanfattning : This thesis consists of four papers, three papers about modelling animal populations and one paper about an area integral estimate for solutions of partial differential equations on non-smooth domains. The papers are: I. Å. Brännström, Single species population models from first principles. LÄS MER

  7. 5. Cell Surface Markers as Therapeutic Targets in Myeloid Leukemia

    Författare :Niklas Landberg; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CML; AML; Cell surface markers; Leukemic stem cells; Myeloid leukemia; Antibody-based targeting; CML; AML; Cell surface markers; Leukemic stem cells; Myeloid leukemia; Antibody-based targeting;

    Sammanfattning : .... LÄS MER