Sökning: "CCN2"

Hittade 2 avhandlingar innehållade ordet CCN2.

1. 1. CCN2 – Keratinocyte Interactions In Vitro and In Vivo

   Författare :Elizabeth Kiwanuka; Bengt Gerdin; Kristofer Rubin; Filip Farnebo; Uppsala universitet; []
   Nyckelord :CCN2; connective tissue growth factor; keratinocytes; re-epithelialization; cell migration; cell signaling; Plastikkirurgi; Plastic Surgery;

   Sammanfattning : Cutaneous wound healing is a complex process involving the migration of inflammatory cells to the wound site, deposition of extracellular matrix, and the reestablishment of an intact epithelial barrier. Re-epithelialization depends on the proliferation and directional migration of keratinocytes from the wound edges. LÄS MER

3. 2. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α : studies in two- and three dimensional in vitro models

   Författare :Anita Koskela von Sydow; Mikael Ivarsson; Torbjörn Bengtsson; Hans Törmä; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblast; Keratinocyte; TGF-β; IL-1α; coculture; fibrosis CTGF CNN 2; dermal; organotypic culture;

   Sammanfattning : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. LÄS MER