Sökning: "Biotransformation"

Visar resultat 6 - 10 av 55 avhandlingar innehållade ordet Biotransformation.

  1. 6. Experimental and computational investigation of affinity and selectivity factors in CYP2D6 and CYP3A4 mediated metabolism

    Författare :Britta Bonn; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; in vitro metabolism; biotransformation; computational modeling; drug design;

    Sammanfattning : The assessment of ADME properties and metabolic behavior of a drug is central in drug discovery and drug design. The main target for studies of metabolic properties is the Cytochrome P450 (CYP), which is responsible for the metabolism of a majority of drugs on the market and consequently also involved in many drug-drug interactions. LÄS MER

  3. 7. Microbial Production of Bio-Based Chemicals: A Biorefinery Perspective

    Författare :Tarek Dishisha; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biorefinery; platform chemical; organic acid; propionic acid; 3-hydroxypropionic acid; 3-hydroxypropionaldehyde; methacrylic acid; 1; 3-propanediol; Propionibacterium acidipropionici; Lactobacillus reuteri; Gluconobacter oxydans; high cell density fermentation; biotransformation; product inhibition; cell recycle; immobilized cells; chemical catalysis; pdu operon;

    Sammanfattning : A shift from fossil- to renewable biomass feedstock for the emerging bio-based economy requires the development and adoption of new sustainable technologies that are more suited for transformation of biomass components to chemicals, materials and energy. This thesis presents investigations on the development of processes based on industrial biotechnology as a key element for the production of chemicals from agro-/industrial by-products. LÄS MER

  4. 8. Enantioselective biotransformations using engineered lipases from Candida antarctica

    Författare :Karin Engström; Jan-E. Bäckvall; Manfred T. Reetz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein engineering; directed evolution; kinetic resolution; dynamic kinetic resolution; biotransformation; lipase; organisk kemi; Organic Chemistry;

    Sammanfattning : Enzymes are attractive catalysts in organic synthesis since they are efficient, selective and environmentally friendly. A large number of enzyme-catalyzed transformations have been described in the literature. LÄS MER

  5. 9. Persistency, bioaccumulation and toxicity assessment of selected brominated flame retardants

    Författare :Jenny Rattfelt Nyholm; Patrik L. Andersson; Peter Haglund; Mats Tysklind; Walter Vetter; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; persistence; bioaccumulation; toxicity; biodegradation; biotransformation; PBT; read across; soil; earthworm; zebrafish; copepod; BFRs; polybrominated diphenyl ethers; tetrabromobisphenol A; hexabromocyclododecane; hexabromobenzene; 2; 4; 6-tribromophenol; tetrabromobisphenol A; 2-hydroxyethyl ether; 1; 2-dibromo-4- 1; 2-dibromoethyl cyclohexane; Environmental chemistry; Miljökemi;

    Sammanfattning : Brominated flame retardants (BFRs) are chemicals used in e.g. electronic equipment, textiles and plastics for the prevention of fire. Over recent decades, concern has been raised regarding some heavily used BFRs, since the levels in the environment have been increasing. LÄS MER

  7. 10. Microbial production of 3-hydroxypropionic acid and poly(3-hydroxypropionate): Investigation of Lactobacillus reuteri propanediol utilization pathway enzymes

    Författare :Ramin Sabet Azad; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Platform chemicals; biopolymers; 3-hydroxypropionic acid; 3-hydroxypropionaldehyde; glycerol; poly 3-hydroxypropionate ; polyhydroxyalkanoates; Escherichia coli; Lactobacillus reuteri; propanediol utilization pathway; propionaldehyde dehydrogenase; biotransformation; cofactor regeneration; NADH oxidase;

    Sammanfattning : Concerns regarding environmental issues such as greenhouse gas emissions and climate change have led to a shift within the research community and chemical and energy industry sectors for finding sustainable routes for producing fuels and chemicals from renewable resources, thereby minimizing our dependence on petroleum. The C3-chemical 3-hydroxypropionic acid has been identifed as a top candidate for the biobased chemical industry. LÄS MER