Sökning: "Bioteknologi"

Visar resultat 16 - 20 av 1000 avhandlingar innehållade ordet Bioteknologi.

  1. 16. Mammalian protein expression and characterization tools for next generation biologics

    Författare :Niklas Thalén; Johan Rockberg; Kerstin Otte; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CHO; Cell line engineering; Protein engineering; GFP; Cell display; Biotechnology; Bioteknologi;

    Sammanfattning : Protein therapeutics are increasingly important for modern medicine. Novel recombinant proteins developed today can bind towards their target with high specificity and with low adverse effect. This has enabled the treatment of diseases that for a few years ago were deemed uncurable. LÄS MER

  3. 17. The ADAPT scaffold as a tool for diagnostic imaging and targeted therapy

    Författare :Emma von Witting; Sophia Hober; Inger Sandlie; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein G; ABD; ADAPT; affinity proteins; antibody; protein engineering; targeted therapy; nuclear medicine; molecular imaging; HER2; radionuclide therapy; Bioteknologi; Biotechnology;

    Sammanfattning : Molecular recognition, or the specific interactions between a protein and its ligand, is central to biology and a key factor for many different clinical and technical applications. Despite antibodies being only one of many different affinity proteins, it has by far been the most successful. LÄS MER

  4. 18. Human iPSC-based models of theCNS: attaining cellular biofidelitythrough conventional and advancedculture systems

    Författare :Dimitrios Voulgaris; Anna Herland; Susanna Narkhilakhi; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neural stem cells; astrocytes; iPSC; hiAstrocytes; microphysiological systems; BBB; Bioteknologi; Biotechnology;

    Sammanfattning : Brain development is a highly orchestrated process that entails changes in microenvironmental cues and growth factor gradients, which set the tempo for proper development of the rudimentary structures of the brain and the generation of neurons,astrocytes, and oligodendrocytes. Another intricate feature of the brain is the bloodbrain barrier (BBB). LÄS MER

  5. 19. Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications

    Författare :Mikael Åstrand; Sophia Hober; John Löfblom; Larry Gold; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Protein G; ERBB2; ERBB3; Directed evolution; phage display; staphylococcal display; bispecific; Bioteknologi; Biotechnology;

    Sammanfattning : Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. LÄS MER

  7. 20. Engineering the extracellular matrix to model diseases and orchestrate regeneration

    Författare :Zackarias Söderlund; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The extracellular matrix is not only a scaffold to which cells attach, but it is also a matrix that communicates cell signals. Because of the interplay between cells and the extracellular matrix, changes in the extracellular matrix can steer cell fate. LÄS MER