Sökning: "BNCT"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet BNCT.

  1. 1. Mixed Beam Dosimetry - From Reactor Core to BNCT Patient

    Detta är en avhandling från Per Munck af Rosenschöld, Dept. of Radiation Physics, Klinikg. 7, 22185 LUND, SWEDEN

    Författare :Per Munck af Rosenschöld; Lunds universitet.; Lund University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dosimetry; BNCT; radiotherapy; mixed beam; quality assurance; in vivo dosimetry; Monte Carlo; ionization chamber; foil activation; MCNP; beam quality correction factor; photon transmission.; Nukleärmedicin; radiobiology; Nuclear medicine; radiobiologi; Radiofarmaceutisk teknik; Radiopharmaceutical technology;

    Sammanfattning : Accurate radiation dosimetry is of paramount importance in order to ensure safe delivery of radiotherapy, and for the possibility of meaningful evaluation of clinical trials, as the radiation absorbed dose is correlated to tissue response. The aim of the studies described in this thesis was to investigate and devise novel approaches to mixed beam dosimetry in boron neutron capture therapy (BNCT). LÄS MER

  2. 2. Liposomes for Drug Delivery from Physico-chemical Studies to Applications

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Nill Bergstrand; Uppsala universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; liposome; steric stabilisation; BNCT; cryo-TEM; EGF; targeting; stability; permeability; pH-sensitive liposomes; triggered release; Fysikalisk kemi; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Physico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. LÄS MER

  3. 3. Synthesis of Organic Compounds for Nuclide Therapy Derivatives of Carboranes, 9-Aminoacridine and Anthracyclines

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Senait Ghirmai; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 9-Aminoacridin; Carborane; Daunorubicin; Doxorubicin; BNCT; Iodine-125; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : This thesis addresses the synthesis of organic compounds, some of them are derivatives of compounds with DNA binding properties, for potential use in targeted nuclide therapy. The compounds synthesized therefore also need to contain potent nuclides. LÄS MER

  4. 4. Transition Metal Mediated Transformations of Carboranes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ludvig Eriksson; Uppsala universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; carborane; isoquinoline; PK11195; peripheral bensodiazepine receptor; Cu I Iodide; iodinated carborane; palladium; isotopic exchange; Herrmann’s Catalyst; Heck reaction; Suzuki-Miyaura reaction; cross coupling; arylation; olefination; 125-iodine; radiolabelling; carboraneboronic ester; BNCT; 2-iodo-; Kemi; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially p-carborane.1-(1-p-carboranyl)-N-methyl-N-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. LÄS MER

  5. 5. Tumor Cell Targeting of Stabilized Liposome Conjugates Experimental studies using boronated DNA-binding agents

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Erika Bohl Kullberg; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; Liposome; EGF; HER-2; Targeting; boron; Biomedicin; MEDICINE Microbiology; immunology; infectious diseases Microbiology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : To further develop cancer therapy, targeted delivery of cell killing agents directly to tumor cells is an interesting approach. This thesis describes the development of PEG-stabilized liposome conjugates targeting either epidermal growth factor receptor (EGFR) using its natural ligand EGF, or human epidermal growth factor receptor 2 (HER-2) using the antibody trastuzumab. LÄS MER