Sökning: "Azadeh Arabi"

Hittade 1 avhandling innehållade orden Azadeh Arabi.

1. 1. Regulation of the ribosomal RNA transcription by c-MYC oncoprotein

   Författare :Azadeh Arabi; Anthony Wright; Robert White; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; Nucleolus; Proteasome; RNA Polymerase; Cancer;

   Sammanfattning : The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon inhibition of proteasomes, excess c-Myc accumulates primarily in the nucleoli. LÄS MER