Sökning: "Association analysis"

Visar resultat 1 - 5 av 1520 avhandlingar innehållade orden Association analysis.

1. 1. Pathway analysis: methods and perspectives

   Författare :Gustavo Stolf Jeuken; Lukas Käll; Mika Gustafsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pathway analysis; mutual information; survival analysis; enrichment analysis; transcriptomics.; Biotechnology; Bioteknologi;

   Sammanfattning : The amount of data being generated by high throughput molecular biology experiments grows every day, both in quantity and quality. With this comes the desire to have more powerful and comprehensive methods for statistical analysis that have been developed with the nature of this data in mind. LÄS MER

3. 2. Exploring the Genetics of SLE with Linkage and Association Analysis

   Författare :Cecilia Johansson; Marta Alarcón-Riquelme; Peter Gregersen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic lupus erythematosus; complex disease; linkage analysis; association analysis; Genetik; Genetics; Genetik;

   Sammanfattning : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. LÄS MER

4. 3. Functional association networks for disease gene prediction

   Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER

5. 4. Global functional association network inference and crosstalk analysis for pathway annotation

   Författare :Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. LÄS MER

7. 5. Early Pottery Use among Hunter-Gatherers around the Baltic Sea

   Författare :Vasiliki Papakosta; Sven Isaksson; Ole Stilborg; Åsa Maria Larsson; Stockholms universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Early Pottery Use; Hunter-Gatherers; Baltic; Late Mesolithic; Ceramics; Ertebølle; Narva; Early Comb Ware; Lipid Extraction; Lipid Residue Analysis; Molecular Analysis; Stable Carbon Isotope Analysis; Elemental Analysis; Mineralogical Analysis; arkeologi med inriktning mot laborativ arkeologi; Scientific Archaeology;

   Sammanfattning : This thesis aims to provide an understanding of the dynamics underlying the adoption of pottery by pre-agrarian hunter-gatherer cultural groups around the Baltic Sea. The focus is on three approximately contemporaneous early pottery traditions of the region (ca. LÄS MER