Sökning: "Anna Karlgren"

Hittade 3 avhandlingar innehållade orden Anna Karlgren.

  1. 1. Genetic Control of Annual Growth Rhythm in the Conifer Norway Spruce (Picea Abies L. Karst)

    Författare :Anna Karlgren; Ulf Lagercrantz; Niclas Gyllenstrand; Janice Cooke; Uppsala universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bud set; circadian clock; Picea abies; growth cessation; phosphatidyl ethanolamine-binding protein PEBP genes; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics;

    Sammanfattning : Norway spruce (Picea abies L. Karst) is a conifer belonging to the group gymnosperms and is an ecologically and economically important species in several parts of Europe. LÄS MER

  3. 2. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo

    Författare :Anna Vildhede; Per Artursson; Maria Karlgren; Maria Kjellsson; Ulf Norinder; Kim Brouwer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OATP1B1; OATP1B3; OATP2B1; NTCP; drug transporters; human hepatocytes; atorvastatin; pitavastatin; proteomics; sandwich-cultured human hepatocytes; SCHH; mechanistic modeling; in vitro-in vivo extrapolation; transport inhibition; hepatic uptake; hepatocyte isolation; transporter contribution; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. LÄS MER

  4. 3. Advanced Mass Spectrometry Imaging in Neuropharmacology

    Författare :Theodosia Vallianatou; Per E. Andrén; Anna Nilsson; Mohammadreza Shariatgorji; Maria Karlgren; Irena Loryan; Nathalie Agar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; neuropharmacology; blood brain barrier; drug-drug interactions; aging; tacrine;

    Sammanfattning : Mass spectrometry imaging (MSI) has emerged as a valuable approach for mapping multiple molecular species in sections of diverse tissues. It enables simultaneous detection of numerous compounds (from neurotransmitters to small proteins) in the brain at relatively high lateral resolution (>5 μm) on a routine basis. LÄS MER