Sökning: "Analytical protocol"

Visar resultat 1 - 5 av 73 avhandlingar innehållade orden Analytical protocol.

  1. 1. Mercury species transformations in marine and biological systems studied by isotope dilution mass spectrometry and stable isotope tracers

    Författare :Lars Lambertsson; Wolfgang Frech; John Munthe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Mercury; methylmercury; ethylmercury; Thimerosal; speciation; methylation; demethylation; brackish water sediment; natural waters; GC-ICP-MS; species-specific isotope dilution; isotope enriched tracers; Analytisk kemi; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : This thesis focuses on the implementation of species-specific isotope dilution (SSID) methodology and stable isotope tracers to determine mercury species occurrence and transformation processes in-situ and during sample treatment. Isotope enriched tracers of methyl-, ethyl- and inorganic mercury were synthesised and applied in different combinations to marine and biological samples. LÄS MER

  3. 2. Methodology for evaluation of hazards from solid waste and landfill-generated leachate

    Författare :Britt-Marie Svensson; Lennart Mathiasson; Lennart Mårtensson; Ann-Sofi Rehnstam-Holm; Kenneth M. Persson; Högskolan Kristianstad; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Analytical protocol; organic pollutants; toxicity test; landfill leachate; leachate treatment; leaching test; waste acceptance criteria; Chemistry; Kemi; NATURAL SCIENCES; NATURVETENSKAP; leaching test; waste acceptance criteria.;

    Sammanfattning : A methodology based on an analytical protocol for evaluation of hazards from landfill leachate and solid waste is described. A dynamic analytical protocol, the LAQUA protocol, including measurements of inorganic and water-quality parameters, polar and non-polar organic marker compounds, and toxicity, was constructed. LÄS MER

  4. 3. Methodology for evaluation of hazards from solid waste and landfill generated leachate

    Författare :Britt-Marie Svensson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; leaching test; waste acceptance criteria.; leachate treatment; landfill leachate; toxicity test; Analytical protocol; organic pollutants;

    Sammanfattning : A methodology based on an analytical protocol for evaluation of hazards from landfill leachate and solid waste is described. A dynamic analytical protocol, the LAQUA protocol, including measurements of inorganic and water-quality parameters, polar and non-polar organic marker compounds, and toxicity, was constructed. LÄS MER

  5. 4. Development of analytical methods for the determination of the small molecule component of complex biological systems

    Författare :Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. LÄS MER

  7. 5. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing

    Författare :Malin Källsten; Jonas Bergquist; Fredrik Lehmann; Sara Lind; Lucia Kovac; Alain Beck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody-drug conjugates; drug-to-antibody ratio; monoclonal antibody; mass spectrometry; hydrophobic interaction chromatography; sample preparation; aggregation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. LÄS MER