Sökning: "Amyloid-beta peptide"

Visar resultat 1 - 5 av 52 avhandlingar innehållade orden Amyloid-beta peptide.

1. 1. NMR studies of the amyloid beta-peptide

   Författare :Jens Danielsson; Astrid Gräslund; Chris Dobson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; Biophysics; Biofysik;

   Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER

3. 2. Amyloid Beta – Biotherapy Target and Biotechnological Tool

   Författare :Sebastian W. Meister; Stefan Ståhl; John Löfblom; Maarten Merkx; KTH; []
   Nyckelord :Alzheimer’s disease; amyloid beta; blood-brain barrier; green-fluorescent protein; intracellular assays; proteases; protease substrate specificity; protein aggregation; protein engineering.; Bioteknologi; Biotechnology;

   Sammanfattning : Alzheimer’s disease is a progressive neurodegenerative disease characterized primarily by memory impairment and cognitive decline. As of 2020, an estimated 50 million people suffer from Alzheimer’s disease or related dementia and no disease-modifying treatment options are yet approved for clinical practice. LÄS MER

4. 3. Structure and dynamics of amyloid-beta oligomers

   Författare :Faraz Vosough; Andreas Barth; Henrietta Nielsen; Oxana Klementieva; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta peptide; Aβ oligomer; infrared spectroscopy; FTIR; protein aggregation; β-sheet; interaction; lithium; nickel; biokemi; Biochemistry;

   Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia, affects tens of millions of people all over the world and inflicts huge socioeconomic costs on the societies. AD is a neurodegenerative disease; it progresses over time and is highly debilitating at the advanced stages. LÄS MER

5. 4. Revealing the complex nature of amyloid beta and its relation to dementia

   Författare :Eleni Gkanatsiou; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s Disease; Amyloid beta; Mass spectrometry; Cerebral amyloid angiopathy; Down Syndrome; Pathological ageing; Dementia with Lewy bodies; Parkinson s disease dementia; dementia;

   Sammanfattning : Alzheimer disease (AD) is the most common type of dementia and characterized by the accumulation of amyloid plaques in the extracellular space of the brain parenchyma. Amyloid plaques consist of amyloid beta peptides (Aβ). Amyloid pathology can also be involved in other types of dementia, either as a driving force or as a coexisting pathology. LÄS MER

7. 5. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

   Författare :Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

   Sammanfattning : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. LÄS MER