Sökning: "Alzheimer s"

Visar resultat 1 - 5 av 84 avhandlingar innehållade orden Alzheimer s.

  1. 1. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

    Författare :Anna-Maria Nilselid; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

    Sammanfattning : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. LÄS MER

  3. 2. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Författare :Kina Höglund; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Sammanfattning : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. LÄS MER

  4. 3. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

    Författare :Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
    Nyckelord :Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. LÄS MER

  5. 4. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

    Författare :Annika Olsson; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

    Sammanfattning : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). LÄS MER

  7. 5. Clinical and etiological studies on dementia of Alzheimer type and multiinfarct dementia

    Författare :Gösta Bucht; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dementia of Alzheimer type; multiinfarct dementia; clinical studies; diagnosis; blood cerebrospinal fluid barrier function; cytogenetic changes; blood glucose; insulin secretion;

    Sammanfattning : 1. Clinical studies. Clinical diagnosis of dementia has been made largely on the basis of clinical findings supported by appropriate radiological and laboratory investigations. A minority of patients have treatable or reversible underlying causes for their dementing syndrome. LÄS MER