Sökning: "Allele sharing"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Allele sharing.

1. 1. Statistical Methods for Genome Wide Association Studies

   Författare :Malin Östensson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome Wide Association Studies; gene-gene interactions; Genotype imputation; allele sharing; haplotype sharing; Single Nucleotide Polymorphism; Celiac Disease; haplotype sharing;

   Sammanfattning : This thesis focus on various statistical methods for analyzing Genome Wide Association data. The thesis include four papers, three of them considers the analysis of complex traits, and the last one a method for analyzing mendelian traits. LÄS MER

3. 2. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

   Författare :Lars Ängquist; Matematisk statistik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

   Sammanfattning : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. LÄS MER

4. 3. Genetic studies of stroke in Northern Sweden

   Författare :Sofie Nilsson Ardnor; Dan Holmberg; Jan Hillert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; linkage; genome wide scan; susceptibility loci; association; candidade gene; PDE4D; PIK3R1; extended pedigree; Medical genetics; Medicinsk genetik;

   Sammanfattning : Stroke is a common disorder of later life with a complex etiology, including both environmental and genetic risk factors. The inherited predisposition is challenging to study due to the complexity of the stroke phenotype. LÄS MER

5. 4. Association studies on susceptibility genes in Alzheimer disease

   Författare :Behnosh Fakhri Björk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Our results support the involvement of genetic variants in IDE; TFAM and COL25A1 in AD cases from Sweden; whereas; it does not for PITRM1.;

   Sammanfattning : Alzheimer disease (AD) is the most common form of dementia in the elderly. Due to the complexity of AD, it has been difficult to find genetic risk factors predisposing to disease. To date, three genes (APP, PSEN1 and PSEN2) with disease causing genetic variants have been reported for the rare early onset monogenic forms of AD. LÄS MER

7. 5. Genetic epidemiology of prostate cancer

   Författare :Fredrik Wiklund; Henrik Grönberg; Douglas Easton; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; prostate cancer; epidemiology; genetics; linkage analysis; genome-wide scan; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Sammanfattning : Prostate cancer is a major health burden throughout the world, yet the etiology of prostate cancer is poorly understood. Evidence has accumulated supporting the existence of a hereditary form of this disease. LÄS MER