Sökning: "Age of onset"

Visar resultat 6 - 10 av 614 avhandlingar innehållade orden Age of onset.

1. 6. The acquisition of contrast : a longitudinal investigation of initial s+plosive cluster development in Swedish children

   Författare :Fredrik Karlsson; Kirk P. H. Sullivan; Peter E. Czigler; Marilyn M. Vihman; Umeå universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; phonological contrast; speech development; place and manner of articulation; aspiration; structural complexity; acoustic cues; homonym production; Phonetics; Fonetik;

   Sammanfattning : This Thesis explores the development of word-initial s+plosive consonant clusters in the speech of Swedish children between the ages of 1;6 and 4;6. Development in the word-initial consonant clusters is viewed as being determined by 1) the children’s ability to articulate the target sequence of consonants, 2) the level of understanding of which acoustic features in the adult model production are significant for the signalling of the intended distinction, and 3) the children’s ability to apply established production patterns only to productions where the acquired feature agrees with the adult target, to achieve a contrast between rival output forms. LÄS MER

3. 7. Prevention of type 2 diabetes : modeling the cost-effectiveness of diabetes prevention

   Författare :Anne Neumann; Lars Lindholm; Katarina Steen Carlsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes mellitus; prevention; health economics; Markov modeling; risk equations; health-related quality of life; lifestyle modification; pre-diabetic states; cost-effectiveness; Västerbotten Intervention Programme;

   Sammanfattning : Background: Diabetes is a common and costly disease that is expected to continue even to grow in prevalence and health expenditures over the coming decades. Type 2 diabetes is the most common diabetes type and is characterized by insulin resistance and relative insulin deficiency. LÄS MER

4. 8. Clinical Aspects of Hereditary Breast Cancer

   Författare :Niklas Loman; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Cytologi; onkologi; cancerology; oncology; Cytology; Age of onset; Survival analysis; Incidence; Male breast cancer; Steroid receptors; BRCA2; BRCA1; Breast cancer; hereditary;

   Sammanfattning : A positive family history of breast cancer (BC) is one of the strongest predictors of the disease. Two major BC susceptibility genes, BRCA1 and BRCA2 were identified about a decade ago. In this thesis, studies of different biological. clinical and epidemiological aspects of hereditary BC are presented. LÄS MER

5. 9. Epidemiological Studies of Preeclampsia : Maternal & Offspring Perspectives 

   Författare :Jóhanna Gunnarsdóttir; Anna-Karin Wikström; Sven Cnattingius; Ulf Högberg; Alexander Smárason; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Placental dysfunction; blood pressure; small-for-gestational-age; fetal growth restriction; intrauterine; prenatal exposure; postnatal height gain; linear growth;

   Sammanfattning : Preeclampsia is a placental-related disorder characterized by generalized endothelial activation. Vascular predisposition is associated with the occurrence of preeclampsia and the recurrence risk is substantial. LÄS MER

7. 10. Health-Related Quality of Life in Asthma

   Författare :Mai Leander; Anna Rask-Andersen; Christer Janson; Alf Tunsäter; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Adult; Quality of Life; Cohort Studies; Longitudinal study; Questionnaires; Epidemiology; Prognosis; Gothenburg Quality of Life Instrument; Göteborg Quality of Life Instrument; MEDICINE; MEDICIN; Caring sciences;

   Sammanfattning : Health-related quality of life (HRQL) has become an important outcome in asthma, since traditional outcomes, such as respiratory symptoms and pulmonary function, might not entirely express the patient’s perception of the limitations caused by the disease. The aim of this thesis was to study HRQL in asthma and to analyse if HRQL was related to asthma onset and prognosis. LÄS MER