Sökning: "Activated protein c resistance"

Visar resultat 16 - 20 av 42 avhandlingar innehållade orden Activated protein c resistance.

  1. 16. HER2 and TP53 in human breast cancer : studies of methods and prognostic value

    Författare :Jenny Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; HER2; c-erbB-2; TP53; tamoxifen; endocrine resistance;

    Sammanfattning : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. LÄS MER

  3. 17. On the role of SAP kinase pathways in cellular responses to cancer treatment

    Författare :Kristina Viktorsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Signal transduction; apoptosis; stress-activated kinases; cisplatin; ionizing radiation;

    Sammanfattning : Inherited or acquired resistance to therapy is a major clinical problem in the treatment of cancer. Defective apoptosis signalling is increasingly acknowledged as an important mechanism of resistance. Better understanding of apoptosis regulation may therefore help improve therapy. LÄS MER

  4. 18. Molecular Subtypes of Melanoma. Biological and Clinical Significance

    Författare :Helena Cirenajwis; Bröstcancer-genetik; []
    Nyckelord :Melanoma; molecular subtypes; gene expression; next generation sequencing;

    Sammanfattning : Cutaneous malignant melanoma (CMM) is the most lethal form of skin cancer and its incidence has increased faster than that of any other cancer, rendering it a major public health problem worldwide. High-throughput screenings have opened the door to a new scientific world, which enables molecular-based characterization of large cancer cohort collections. LÄS MER

  5. 19. Kinase cascades in the regulation of glucose homeostasis

    Författare :Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Sammanfattning : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. LÄS MER

  7. 20. Effects of combined oral contraceptives on hemostasis and biochemical risk indicators for venous thromboembolism and atherothrombosis

    Författare :Marianne van Rooijen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Combined oral contraceptives; emergency contraception; menstrual cycle; ethinylestradiol; levonorgestrel; desogestrel; lipoproteins; hemostasis; risk indicators; APC resistance; SHBG;

    Sammanfattning : Combined oral contraceptives (COCs) are one of the most common contraceptive methods in the world. Already a few years after their introduction, in the early 1960s, case reports were published showing associations between use of COCs and venous and arterial thromboembolism. LÄS MER