Sökning: "Acetyl CoA carboxylase"

Hittade 4 avhandlingar innehållade orden Acetyl CoA carboxylase.

  1. 1. Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance

    Författare :Jeanette Kuhl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetyl CoA carboxylase; AMP-activated protein kinase; Glucose intolerance; Insulin secretion; Insulin sensitivity; Malonyl CoA; Malonyl CoA decarboxylase; Peroxisomal proliferator activated receptor ã co-activator 1 á; Type 2 diabetes heredity;

    Sammanfattning : Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired insulin responsiveness. LÄS MER

  3. 2. Molecular mechanisms of estrogen action in relation to metabolic disease

    Författare :Lovisa Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. LÄS MER

  4. 3. Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs

    Författare :Emilia Heimann; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; type 2 diabetes; islets of Langerhans; adipocytes; PDE3B; OPN; SCFAs;

    Sammanfattning : Type 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. LÄS MER

  5. 4. Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin

    Författare :Yun Chau Long; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; metabolism; glucose; lipid; gene expression; AMP-activated protein kinase; calcineurin; exercise;

    Sammanfattning : Skeletal muscle fibers differ considerably in their metabolic and physiological properties. The metabolic properties of skeletal muscle display a high degree of flexibility which adapts to various physiological demands by shifting energy substrate metabolism. LÄS MER