Sökning: "ATP-bioluminescence assay"

Hittade 2 avhandlingar innehållade orden ATP-bioluminescence assay.

1. 1. Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines

   Författare :Kerstin Jönsson Videsäter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Multidrug resistance; cross-resistance profile; ATP-bioluminescence assay; pglycoprotein; MRP1; selenium; thioredoxin reductase; glutathione reductase.;

   Sammanfattning : Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of multidrug resistance and to establish in vitro methods to characterize the resistant tumor cell phenotype. LÄS MER

3. 2. In vitro studies of cytostatic drugs and growth factors on leukemic and normal hematopoietic cells : based on in vivo intracellular pharmacokinetics

   Författare :Britt Sundman-Engberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ANLL; Normal bone marrow; in vitro; predictive tests; pharmacokinetics; cytostatic drugs; growthfactors;

   Sammanfattning : The aims were to develop, evaluate and apply in vitro methods for cytostatic drug sensitivity, based on intracellular concentrations found after in vivo infusions. The intracellular pharmacokinetics of anthraquinones and ara-C were compared during and after infusion to leukemic patients. Drug concentrations were evaluated with HPLC. LÄS MER