Sökning: "AAT polymerization"
Hittade 3 avhandlingar innehållade orden AAT polymerization.
1. Chronic Obstructive Pulmonary Disease: Role of Alpha-1-antitrypsin
Sammanfattning : The only proven genetic risk factor for Chronic Obstructive Pulmonary Disease (COPD) is an inherited Z (Glu342¡úLys) deficiency of alpha-1-antitrypsin (AAT), a major inhibitor of neutrophil elastase. In vivo, AAT is found in both native (inhibitory) and modified (non-inhibitory) forms. LÄS MER
2. Hydrophobic interactions of serpins
Sammanfattning : The proteins of the serpin family are primarily but not exclusively proteinase inhibitors, which share a common, similar structure. It is known that this structure undergoes major conformational changes upon cleavage in the serpin reactive site loop, and that these changes include rearrangements within the hydrophobic core of the molecule. LÄS MER
3. Severe and moderate alpha-1-antitrypsin deficiency at the age of 30
Sammanfattning : Alpha-1-antitrypsin (AAT) is a glycoprotein synthesised in the liver. Its main role is to protect lung tissue from destruction by neutrophil elastase. In severe (PiZZ) AAT deficiency, there is an increased risk of emphysema, especially in smokers. LÄS MER