Sökning: "5q- syndrome"
Hittade 5 avhandlingar innehållade orden 5q- syndrome.
1. Identification and Characterization of Stem Cells in Preleukemia and Leukemia
Sammanfattning : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. LÄS MER
2. TP53 mutations in myelodysplastic syndromes with deletion of 5q
Sammanfattning : The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia(s) and increased risk of progression to acute myeloid leukemia (AML). International Prognostic Scoring system (IPSS) Low- or Intermediate (INT)-1 risk MDS with a deletion of 5q (del5q) were considered to have an indolent course and a low risk for progression to AML as compared to other MDS subtypes. LÄS MER
3. Studies of anemia in the myelodysplastic syndromes
Sammanfattning : Background: The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders, characterized by chronic anemia and increased risk of transformation to acute myeloid leukemia (AML). The first line therapy of anemia in MDS is erythropoietin (EPO) with or without granulocyte colony-stimulating factor (G-CSF). LÄS MER
4. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene
Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER
5. Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
Sammanfattning : Increased apoptosis of hernatopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe anemia observed in the low-risk subgroups, refractory anemia (RA) arid RA with ringed sideroblasts (RARS). LÄS MER