Sökning: "β-lactam antibiotics"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden β-lactam antibiotics.
1. Neurotoxicity of β-lactam antibiotics : experimental kinetic and neurophysiological studies
Sammanfattning : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. LÄS MER
2. Antibacterial Effect and Inflammatory Response in Relation to Antibiotic Treatment of Sepsis
Sammanfattning : Sepsis defines as life-threatening organ dysfunction caused by a dysregulated host response to infection. The importance of early administration of antibiotics in septic shock is undisputed, but the optimal antibiotic choice remains uncertain. LÄS MER
3. Prognostic assessment in community acquired pneumonia
Sammanfattning : Community acquired pneumonia (CAP) is the most commonly occurring infectious disease that requires hospital admission. CAP affects mainly, the youngest, the oldest, the poorest and the sickest. Annual incidence is 5-12 per 1000 adults. Between 20% and 40% of patients with CAP need in-hospital treatment. LÄS MER
4. Individualized treatment and control of bacterial infections
Sammanfattning : Infectious diseases cause substantial morbidity and mortality, exacerbated by increasing antibiotic resistance. In critically ill patients, recent studies indicate a substantial variability in β-lactam antibiotic levels when standardized dosing is applied. LÄS MER
5. Antibiotic-induced Bacterial Toxin Release – Inhibition by Protein Synthesis Inhibitors
Sammanfattning : Toxic products, such as endotoxin from the gram-negative and exotoxin from the gram-positive bacteria, are the most important initiators of the inflammatory host response in sepsis. In addition to antibacterial treatment, numerous attempts have been made to interfere with the exaggerated proinflammatory cascade initiated by the toxins. LÄS MER